![]() ![]() It can be concluded that even small doses of prednisone, administered over a prolonged period of time, can induce extreme and persistent leukocytosis. Can steroids cause neutrophilic leukocytosis? Without this replacement, the neutrophil will detach (or undergo “demargination”) to then enter into the circulatory compartment. Glucocorticoids are known to decrease gene transcription of L-selection thereby decreasing the amount produced and transferred to the surface to replace recently shed L-selectin. The increase in WBC count is primarily contributed from neutrophils (polymorphonuclear leukocytes PMN). ![]() ![]() Summary: Glucocorticoids (e.g., dexamethasone, methylprednisolone, prednisone) are known to increase the white blood cell (WBC) count upon their initiation. ![]()
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